I would like to thank all who have provided information to be placed in the newsletter. The only way we are able to have the newsletter we all desire is through sharing. Please keep your brags, photos, and club related information coming. Please feel free to share any suggestions you might have with me at Fitchpatrick@Earthlink.net

The evite invitation for the March 2020 Puppy Picnic was emailed to members on November 12. Please be sure to RSVP for the event.

We will be holding our Holiday Luncheon on Sunday, December 15, 2019, from 1 pm to 5 pm at the home of club member Margie Roe. The club will be providing the ham, iced tea, water and set up. Please bring a dish to share! Evite invitations were emailed this month to club members. Please be sure to RSVP to the EVITE invitation. There is also a poll where you can indicate what type of dish you are planning to bring to the luncheon. We will also be celebrating our member’s achievements and membership awards along with the club Member of the Year Award. We will have our ‘white cavalier’ gift exchange also. If you wish to participate, please bring an unmarked, wrapped gift valued between $25 and $30 dollars. We will also be supporting Pickens Animal Rescue Ranch again. Please bring donations of items (they are listed on the Evite invitation) or you can donate money directly to the Ranch via the link on the Evite invitation.

American Cavalier King Charles Spaniel Club, Inc.

Official AKC Parent Club

Press Release

November 4, 2019

The American Cavalier King Chares Spaniel Club and the ACKCSC Charitable Health Trust are proud to announce that Rejuvenate Bio, in conjunction with the Cummings School of Veterinary Medicine at Tufts University and the ACKCSC, Inc. through its Charitable Trust will launch the Mitral Valve Disease Trial this month. This study will be featured in the Wall Street Journal

on November 4, 2019. We are extremely excited to have this exposure in a major, respected

national publication.

Please see the attached Rejuvenate Bio explanation of this groundbreaking gene therapy in canines.

Contact:

Lu Dunham, Secretary

ACKCSC Charitable Trust Board of Trustees

corrsec@ackcsc.org

Daniel Oliver

Rejuvenate Bio

info@rejuvenatebio.com

A SOLUTION FOR MITRAL VALVE DISEASE

Novel gene therapies for dogs

Over seven million dogs in the United States alone have Mitral Valve Disease (MVD). For certain breeds, such as Cavalier King Charles Spaniels, more than 80% of dogs will be afflicted with MVD. Rejuvenate Bio is developing a novel cardio-protective gene therapy to stop the progression of heart failure in dogs. In partnership with the American Cavalier King Charles Spaniel Club (ACKCSC), Rejuvenate Bio has launched a study in dogs with Mitral Valve Disease (MVD). This study will provide valuable information that will aid our effort to address MVD.

FAQ

How would the therapy work?

Rejuvenate Bio’s therapy is a gene therapy similar to others that have been approved for use in humans. It does not edit or change any genetic material in animals. Instead, it introduces a new piece of DNA into the dog’s cells, which then produces a beneficial protein with the potential to stop the progression of MVD. This is done by halting the build-up of scar tissue in the heart, which is connected with the progression of heart failure. This newly introduced piece of DNA is not passed on to the next generation and is not transmissible between dogs.

What have you seen so far?

Our approach has demonstrated the ability to stop the progression of heart failure in mice. After receiving our treatment, mice with heart failure had cardiac measurements that are similar to those of normal mice and exhibited up to 85% less scar tissue in their hearts, compared with mice that received a mock therapy (unpublished data). We conducted a safety study in dogs and have seen no adverse side effects.

For which dog breeds and diseases could this treatment be relevant?

We will test our new therapy in dogs with MVD across all breeds, but are starting with a trial in Cavalier King Charles Spaniels. Since the treatment works to suppress fibrotic processes, we believe it could be applied to other heart diseases such as Dilated Cardiomyopathy (DCM) in the future.

How does this affect breeding programs? Will this mask dogs that have heart failure and allow them to continue to breed? Shouldn’t we just try to breed MVD out of the dog population?

While breeding MVD out of the dog population is worthwhile, efforts to date have been unsuccessful for a number of reasons. For example, MVD symptoms often do not present until later in life — after the start of breeding. Genetic tests have yet to identify a single gene (or a specific combination of genes) that can accurately predict, or identify, a predisposition for MVD. In the meantime, we are doing our best to create a treatment that may extend and improve the quality of life for the dogs that we love.

CBD OIL FOR DOGS

As with any pet wellness trend, when it comes to CBD oil for dogs, there’s a lot of information floating around online. Of course, you want to do what’s best for your pup, which leads to the question: What do I need to know about CBD oil?

The AKC’s Chief Veterinary Officer, Dr. Jerry Klein, explains what CBD oil is, what it does, and its safety concerns and side effects.

What Is CBD Oil?

CBD, or cannabidiol, is a compound found in cannabis and hemp. Dr. Klein says it is essential to note that in most cases, CBD does not contain delta-9-tetrahydrocannabinol (THC), the compound that gives marijuana its psychoactive properties. In fact, most CBD products are derived from hemp and not from marijuana.

How Does CBD Affect Dogs?

Currently, there has been no formal study on how CBD affects dogs. What scientists do know is that cannabinoids interact with the endocannabinoid receptors located in the central and peripheral nervous systems, which help maintain balance in the body and keep it in a normal healthy state.

What Dog Health Problems Can CBD Oil Treat?

While there’s no definitive scientific data on using CBD to treat dogs, there’s anecdotal evidence from dog owners suggesting it can treat pain, especially neuropathic pain, as well as helping to control seizures.

According to Dr. Klein, CBD is also used because of its anti-inflammatory properties, cardiac benefits, anti-nausea effects, appetite stimulation, anti-anxiety impact, and for possible anti-cancer benefits, although there’s no conclusive data on this use.

The AKC Canine Health Foundation (CHF) is sponsoring a study, through the Colorado State University’s College of Veterinary Medicine and Biomedical Sciences, that will evaluate the use of CBD in treatment-resistant epileptic dogs. The CHF hopes that this will be the first study to gain scientific data on the use of CBD in dogs with this condition.

Possible Side Effects of CBD in Dogs

While there’s no scientific data on the side effects of CBD usage for dogs, there are potential side effects based on how CBD affects humans. To minimize any potential side effects, make sure you are following the proper dosage.

• Dry mouth: Research has shown that CBD can decrease the production of saliva. For dogs, this would manifest as an increased thirst.
• Lowered blood pressure: High doses of CBD have been known to cause a temporary drop in blood pressure. Even though the drop is small, it might create a brief feeling of light-headedness.
• Drowsiness: Dog owners have used CBD to treat anxiety. The calming effect of CBD can also cause slight drowsiness, especially when using higher doses.

Risks of Using CBD Oil for Dogs

The safety and risks of using CBD for dogs have not yet been researched. The U.S. Food and Drug Administration has not approved CBD and has not issued a dosing chart. Therefore, we do not know what size dosage would be toxic. Any medication or supplement carries the risk of a reaction. It is always advisable, when giving your dog something new, to start out with small amounts and then closely monitor the effects. And always check with your veterinarian first.

CBD Products on the Market

If you and your veterinarian decide that you should try CBD as a treatment for your dog, there are a few things to keep in mind when purchasing CBD oil. Not all oils are the same; you’ll want high-quality CBD oil to have a better chance of it working.

• Look for organic. If the CBD oil is not organic, it at least should not contain pesticides, fungicides, or solvents.
• Don’t price shop. The higher the quality and purity, the higher the cost. You don’t want to go for a cheaper option that could have toxic substances such as pesticides, herbicides, or heavy metals. Make sure your CBD oil is free of additives.
• Get the analysis. The manufacturer should provide a certificate that tells you the amount of CBD that is in the product. Many CBD products contain only small amounts of CBD. You’ll also want to make sure there is little or no THC in the product.
• Buy CBD as a liquid. You can buy dog treats containing CBD, but the best form to administer is an oil or tincture. This way, you can adjust your dog’s dose drop by drop.

The CBD Wellness Trend

Why are we hearing so much about CBD oil now? Dr. Klein points to the legalization of marijuana in many places, which has triggered interest in potential health benefits of marijuana-related products. “We are likely to see continued interest in CBD and an increase in research about its uses and efficacy in the coming years,” he says.

Learn more about the CBD study funded by the Canine Health Foundation.

Innovet created a product line of full spectrum pure hemp oils void of dangerous compounds. Their USDA certified organic oil is formulated especially for animals and is also third-party tested to ensure consistency and purity. Innovet offers more than 50 affordable products to help pets manage anxiety, pain, as well as other conditions. Get more information about Innovet’s CBD products.

By Randa Kriss

Sponsored by Innovet Pet Products
AS PUBLISHED ON THE AKC WEBSITE

ALWAYS CONSULT YOUR VET PRIOR TO USING ANY TREATMENT ON YOUR PET

3 CBD Dog Treat Recipes To Delight and Nourish Your Four-Legged Friends

DOG DREAM CBD

Date Published: 2019-03-10

Date Updated: 2019-03-10

There are many benefits of CBD oil for dogs, which is why so many dog-lovers buy CBD dog treats for their furry friends. But did you know that you can make your own CBD-enriched dog treats at home? Here are a few easy recipes for CBD dog treats.
Please note that the measurements of CBD oil assume your dog uses one drop a day. Please check our dosage chart and adjust accordingly.

No-Bake Pumpkin and Turmeric CBD Dog Treats

These no-bake treats are perfect for dogs with inflammatory conditions. Both CBD and turmeric have anti-inflammatory properties, and the crack of black pepper helps your dog absorb the goodness of turmeric.

Makes 14

• 2 cups pumpkin puree*
• 3 tbsp. honey
• 2 cups rolled oats
• 3 tsp. turmeric
• 3 tbsp. coconut oil
• CBD oil

*Ensure that the pumpkin puree is pure pumpkin with no added preservatives or sweeteners. Be especially careful to avoid xylitol, a common sweetener that’s extremely toxic to dogs, even in small doses.

• Mix the pumpkin, honey, turmeric, coconut oil, and black pepper in a bowl until it’s all mixed together well.
• Add the rolled oats. You might want to add more or less oats to make it the right consistency. It should feel like a cookie dough consistency.
• Put parchment paper on a small baking sheet. Break off equal pieces of cookie dough and roll them into balls. A melon scooper or ice-cream scoop might be helpful. Ideally, you’d want to get about 14 balls out of this mixture, but the final number depends on how large the balls are.
• Now it’s time to add the CBD oil. The amount of oil you add depends on how much your dogs need. Assuming your dogs need one drop of CBD oil a day, add one drop to each treat and give them one treat a day. If you’re unsure which dosage to use, check our CBD oil for dogs dosage chart.
• Place the balls in the fridge so that they can harden. This should take 15 minutes.
• They can be refrigerated for about two weeks.

Since this recipe makes 14 and lasts about two weeks, you can give your dog one a day, every day!

Peanut Butter CBD-Enriched Dog Cookies

These dog cookies combine the deliciousness of apple sauce and peanut butter with the goodness of CBD oil. They’re sure to be a hit with your furry friends!

Makes 20

You’ll need:

• 1 cup apple sauce *
• ½ cup peanut butter *
• ¼ cup coconut oil
• 3 cups flour
• 1 tsp. baking soda
• CBD oil

*Ensure that the apple sauce and peanut butter don’t contain toxic preservatives or sweeteners. Be especially careful to avoid xylitol, a common sweetener that’s extremely toxic to dogs, even in small doses.

• Preheat the oven to 340 degrees Fahrenheit (170 degrees Celcius).
• Mix the apple sauce, peanut butter, and coconut oil in a bowl.
• Add the baking soda and flour while stirring.
• Mix until everything is well-combined. Ideally, you’d like it to be a dough-like consistency. If necessary, add more flour or a little water to change the consistency.
• Roll the dough into small balls. Alternatively, roll the dough out and use cookie cutters to divide them up. You want them to be about a quarter of an inch (half a centimeter) in thickness.
• Put parchment paper or wax paper on a baking sheet. Add the cookie dough to the sheet. Bake for about 15 minutes.
• Once cooled down completely, add the CBD oil to the cookies. If your dog needs one drop of CBD oil a day, add one drop to each treat. Allow the oil to soak into the cookies.

Store the biscuits in an airtight container. Give your dog one treat a day, or more if they need an extra dose.

Sweet Potato and Yogurt CBD-Enriched Dog Treats

This is also a no-bake recipe that is super easy to do. The mashed sweet potato can be exchanged for mashed pumpkin. These delicious cold treats are perfect for the warm summer months!

The number of treats this recipe yields will depend on the size of your molds.

You’ll need:

• 1 cup sweet potato, cooked and mashed
• ½ cup plain yogurt
• 1 tbsp. coconut oil
• CBD oil
• Mix the yogurt with the sweet potato mash and coconut oil in a large bowl. Ensure it’s mixed thoroughly.
• Scoop the mixture into silicon molds or ice trays.
• Add CBD oil to each treat. If your dog needs one drop of CBD oil a day, add one drop to each treat.
• Put the trays or molds into the freezer for about three hours.
• Store in the freezer until ready to serve.

Give your dog one a day, or more to increase the dosage.

We have a wonderful club, one to be very proud of. The way to have an even better club is through member participation. Over the next couple of months, a great deal will be discussed and decisions made. We have several events on the horizon.....Monthly Meetings, Holiday Party, Specialty Show. We are all pieces of the puzzle; the way to share your ideas is by attending our meetings and voicing your opinion. Please make an extra effort to attend our meetings at Red Lobster, shows, and events.

Do you know a club member who needs some sunshine? Please contact Maureen Miles and she will send a card on behalf of the membership to brighten that person's day! Maureen can be contacted at 404 791-8422 or maureenvmiles@gmail.com.

CAVALIER KING CHARLES SPANIEL CLUB OF GREATER ATLANTA

www.ckcscatlanta.org